Hi,   I am currently on Sandomigran, and it works pretty well for me. Definatly takes the edge of and keeps me going.   As far as I know Endep is a anti-depressant? I was undiagnosed for about 10 years and was constantly told I had 'emotional' problems, hence many anti-depressants were tried. Endep was one I tried but it just plain knocked me out. I was a walking Zombie!   Currently I am taking Cipramil (antidepressant),which I have been on for yonks - and is has always helped just a little. Once I was finally diagnosed they put me on Sandomigran and within 2 weeks I was a new person. So it instantly worked really well for me.   Each night I take, Cipramil, Sandomigran, Vitamin B12, Magnesium, and Iron. This combination works really well for me. Although it has taken 10 years to get to this point.   Keep plodding along and keep speaking to your Doctors. If one med isn't working for you there are many more to try.   Good luck.