Tuesday, May 29, 2012
Friday, January 29, 2010 Calla asks

Q: DHE, anyone else trying this?

I've tried just about everything over the years and have recently had great success with imitrex...more recently with the sumitriptan.  Then, in October, I had a headache that lasted for several weeks.  I was told it was a medication rebound headache from taking too much of the sumitriptan.  I had to get off the medication and the Headache Clinic where my doctor practices put me in a week long clinic using IV DHE (Dihydroergotamine mesylate)to wean me off the sumitriptan and treat my ongoing migraine.

 

The medication does make me sick to my stomach, however, so I have to take zofran with it (I'm allergic to compazine or they would have given me that)  Now I give myself injections to treat my headaches, but I've heard that there is an inhaler in the works which would certainly be easier than trying to draw out of that little vial into a syringe when I have a brutal migraine.  Has anyone else used this medication and does anyone know anymore about the inhaler version of the DHE?

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Answers (1)
Teri Robert, Health Guide
1/31/10 5:12pm

Hi, Calla,

 

I've never used DHE, but certainly, it's effective for many Migraineurs. The same medication is available as a nasal spray called Migranal.

 

The inhaler you're asking about is called Levadex, and it's still in clinical trials. You can read more in New Migraine Drug Levadex Performs Well in Trials.

 

Hope this is the info you needed.


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1/31/10 8:15pm

My doctor gave me the Imirex inhaler one time but it turns out with my sinus condition, a nasal inhaler isn't for me, so I never tried Migranal and didn't realize DHE was in the migranal.  The inhaler I heard about was oral so I assume it was the Levadex.  I'll do some reading on this.  Thanks for the information.

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Teri Robert, Health Guide
2/ 1/10 11:19am

Calla,

 

Let's see if I can make things a bit clearer for you. There's a big difference between Imitrex nasal spray and the Levadex inhaler.

 

Imitrex, Zomig, and Migranal nasal sprays aren't inhalers; they're nasal sprays. They're in bottles that you squirt into your nostrils.

 

The Levadex inhaler is the first Migraine medication to be delivered via an inhaler that's similar to an asthma inhaler. It's inhaled through the mouth into the lungs.

 

Does that help?

 

Teri

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By Calla— Last Modified: 12/20/10, First Published: 01/29/10