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Nancy, when every anti-hypertensive has lowered my blood pressure to a dangerous level, most doctors aren't going to want to try another one.  It isn't worth the potential legal issues.  Same thing goes for meds that make someone homicidal or suicidal.  By now, I am more than aware that meds take 3-4 months before one sees the full effect.  The ones that haven't worked (and been disgarded) were tried for 4-6 months.  The ones that caused ill effects are the   I've already read the previously mentioned articles.  Other than some of the non-FDA approved (and no to very limited peer reviewed material), I'm not seeing anything more than someone who is going to want to either start over from scratch or start from the top of those meds left that I haven't tried, complely disregarding why the rest of the family has been marked off the list.  I'm also skeptical of the success rates that some of migraine specialists are claiming.  If your success rate is soo far above the norm, why not publish and make your findings more widely known?