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I have been on Topamax for a year and lost 110lbs.  The way it worked for me is I became fuller quicker and a loss of appettite.  I took this opportunity to start eating healthy and the weight just fell off for me.  I've known a few others who were on Topamax and they said the same thing - they had to listen to their bodies and pay attention that they became full quickly.  If you ignore that, then it will not help you with weight loss, I think...
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