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Tuesday, February 09, 2010 Michelle, Community Member, asks

Q: I recently started taking topamax at night for one week.

I don't see how I can function at work taking Topamax in the a.m.  It makes me sleepy and dizzy.  Can it be taken at night only to be effective on migraines?

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Answers (2)
Teri Robert, Health Guide
2/11/10 1:06pm



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Topamax dosage needs to be tapered up slowly, and once you're above 25mg, it need to be split into two doses. There are couple of reasons for the split dosing:


1. The half-life of Topamax is short enough that it doesn't maintain a steady level in your system if taken only once a day. If the level isn't kept steady, it's less likely to work.

2. Side effects, if they occur, are worse at higher dosages, so split dosage reduces the likelihood of those side effects.


Something to keep in mind is that the side effects may stop as your body becomes more accustomed to the medication. You can find information on Topamax, including a dosage schedule, in Topamax Info.


Please keep me posted on how you're doing?


Welcome again,


Headacut, Community Member
2/ 9/10 2:13pm



I had the same problem especially the first month.  By the third month the dizziness was pretty much gone.  My doctor told me it didn't matter when I took the Topomax and that the sleepiness was a common side effect so I opt to take mine at night.  I do continue to get my dosage in 25mg pills though so I can play with my 100mg daily dosage as I feel helpful.  Lately to break a long stretch of morning migraines I have been taking 75 mg at night and 25 mg in the wee early morning hours before I have to actually get up and this seems to help shake up the migraine pattern.  Good luck and hopefully your side effects will end lin a few weeks as your body adjusts.

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By Michelle, Community Member— Last Modified: 12/27/10, First Published: 02/09/10