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I lost about 30 pounds over a year.  Topomax did not stop my headaches - it made my imitrex tablets work again.  I found the side effect of topomax to be AWFUL.  It negatively affected my memory, my ability to express myself and my personality.  I would go completely blank when I needed to speak in public.  I became quick tempered and generally disagreeable.  Eventually, my doctor took me off topomax and started me on depakote.  Then I gained 40 lbs in about five months.  So I would not advise getting rid of clothes.  You may need them on your way back up to a bigger size in the future.