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I've been on and off Topamax for about a year.  It kind of depends on my dosage.  When I go over 100, I lose more.  But the more I take, the worse the side effects are.  I stopped at about 100 mg per day and stopped my weight loss at 20 pounds.  A friend of mine was on about 250 mg per day and lost 40 pounds before she stopped losing. 
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