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I think it depends on what your dose is. I lost about 20 pounds when I was on Topomax at 200 mg twice a day (the first time). I had to stop taking such a high dose though because it gave me kidney stones. After a year I went back on it and I am at 100 mg twice a day and I lost maybe 5 pounds at most. The most important thing about Topomax is to stay well hydrated. Drink lots and lots of water and try to stay away from iced tea and ice cream. That is what triggered the kidney stones in my case.
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