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Friday, December 4, 2009
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Winter Holiday GuideEnjoying the Holidays Despite Migraines and Headaches --> Info for you...

Depakote Oral

Precautions and Side Effects

(Page 2)




Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • chest pain
  • easy bruising/unexplained bleeding
  • fast/irregular heartbeat
  • swelling of hands/feet
  • uncontrolled eye movement (nystagmus)


This medication rarely may cause mood or behavior changes, such as anxiety, agitation, hostility, pressured/rapid speech, or thoughts of suicide. Tell your doctor immediately if you develop unusual (possibly sudden) mood changes.

Tell your doctor immediately if any of these highly unlikely but very serious side effects occur:

  • dark urine
  • persistent nausea/vomiting
  • severe stomach/abdominal pain
  • yellowing eyes or skin


Severe (sometimes fatal) brain disorder (encephalopathy) has rarely occurred, particularly in patients with certain metabolic disorders (urea cycle disorders). Tell your doctor immediately if you develop unexplained weakness and vomiting or sudden mental changes.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. In the US, you may report side effects to the Food and Drug Administration (FDA) at 1-800-FDA-1088.

In Canada, you may report side effects to Health Canada at 1-866-234-2345.

Depakote Oral Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA) or 1-800-668-1507 (Canada).

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