Can Migraines Occur In First Trimester Pregnancy?

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Migraines, Pregnancy, and Topamax: New FDA Warning

The FDA has issued new warnings about Topamax (topiramate) a medication sometimes used for Migraine and headache prevention. New information from the North American Antiepileptic Drug (AED) Pregnancy Registry shows an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy. Oral clefts are cleft lip and cleft palate.


Russell Katz, M.D., director of the Division of Neurology Products in the FDA’s Center for Drug Evaluation and Research,...

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