Can Quitting Tricyclic Antidepressant Cause Migraine Headaches?

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Medication Profile - Amitriptyline Off-Label for Migraine

There's a wide variety of medications used for Migraine, most of which are prescribed off-label. If amitriptyline has been prescribed for you, or if you and your doctor have been considering it, here's some information that should be helpful.

Type of medication:

Amitriptyline is a tricyclic antidepressant that has also been prescribed off-label as a Migraine and headache preventive for many years. It was, in fact, among the first medications recognized as a potential preventive.
 

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Cause of headaches

Learn the role that the trigeminal nerve plays in causing cluster headaches in this diagram... Read more »