Conclusions:
We conclude that IV lidocaine can be used in the clinic for treatment of refractory Migraines and that sodium channel over-activity may be playing a role in the maintenance or perpetuation of Migraine attacks. Lidocaine is safe, very effective and very well tolerated, but must be monitored. Successful treatment may allow choice of a sodium channel active agent for oral prophylaxis of Migraines. The study also raises questions about mechanisms of aberrant neurotransmitter activity involving sodium channels playing a role in refractory Migraine.
Resources:
Cammarata, Diane, APRN,BC; Cagle, Jane, LVN; Krusz, John Claude, PhD, MD. “IV Lidocaine – Effective Treatment for Refractory Migraines in the Clinic.” Research Poster Presentation. 49th Annual Scientific Meeting of the American Headache Society. Chicago. June, 2007.
Last Updated: July 30, 2007
