Leukotriene-Antagonists. Leukotriene-antagonists are anti-inflammatory drugs that block leukotrienes, powerful immune system factors that are important in causing airway constriction. They include zileuton (Ziflo), zafirlukast (Accolate), montelukast (Singulair), and pranlukast (Ultair, Onon). These drugs are being used in asthma, and some doctors have observed a reduction in migraine frequency in asthmatic patients who also had these headaches. In one study that investigated the use of these drugs for migraine prevention, more than half of patients experienced a reduction in frequency of severe attacks. In a controlled study, however, montelukast had no effect on migraines.
Dopamine Agonists. Alpha-dihydroergocryptine is a drug known as a dopamine agonist, which may help prevent common migraine (without aura).
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