"This observation provides insight in to the effects of alcohol on trigeminal pain. This is the first demonstration of an inducible headache in a rat model that uses a trigger that also induces headaches in the humans. Future directions include examining the cellular mechanism behind this phenomenon."1
Michael Oshinsky, assistant professor of neurology at Thomas Jefferson University and a member of the Jefferson Headache Center team commented:
"Our results suggest that dehydration or impurities in alcohol are not responsible for hangover headache... Since these rats were sufficiently hydrated and the alcohol they received contained no impurities, the alcohol itself or a metabolite must be causing the hangover-like headache."
Summary and comments:
Although this research didn't identify the exact cause of the hangover-like headaches, it did successfully rule out dehydration and impurities in the alcohol. This is a vital first step.
Until researchers understand the functional changes that occur to trigger Migraine attacks and the functional changes that occur during Migraines, they lack knowledge vital to developing truly effective treatments, let alone pursuing a cure for Migraine disease. The importance of such basic research cannot be overstated.
1 Maxwell, CR; Oshinsky, ML. "Alcohol induces headache in a rat model of migraine." 14th International Headache Congress. Philadelphia. September, 2009.
2 Katyal, Sugita. "Migraine Sufferer? Hangover likely to be worse, study shows." Reuters Life! October 19, 2009.
3 Preidt, Robert. "Hangovers May Be Tougher for Migraine Sufferers." HealthDay News. October 19, 2009.