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Wednesday, March 18, 2009 Amanda asks

Q: I have two sisters (one older half sister and my only, younger full sister) who have been diagnosed

My older sister has had MS for a few years.  My younger sister has just been diagnosed with MS.

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Answers (2)
Lisa Emrich, Health Guide
3/18/09 10:54pm

Hi Amanda,

 

Sorry, I can't really see your question, but think I knew what you might be asking.

 

Multiple sclerosis is thought to be triggered by a combination of risk factors, one of which may be found in genetics.  Here is an excerpt from paper entitled The Basics of Genetics of Multiple Sclerosis.

 

"The risk of developing MS in people who have no relatives with MS is about 1 in
1,000. Eighty percent (80%) of people who develop MS have no relatives with MS, and
20% have at least one affected relative with the disease. The risk of MS in the siblings of a person with MS is significantly higher. A measure of the size of the genetic component of disease susceptibility is the sibling risk, which is defined as the ratio of the disease risk in a sibling of an affected individual to the general population. The sibling risk for MS may range from 1 in 20 to 1 in 50. As one moves from siblings to first and third cousins, the risk decreases. However, the first, second, and third-degree relatives of people with MS are more likely to have the disease than the general population (Dyment, Ebers, & Sadovnick, 2004).

The half-sibling and full sibling studies showed a 2.35% for MS in siblings with a shared
mother who had MS, and 1.31% for a shared father who had MS, indicating a maternal
effect. The risk of transferring MS from mother to siblings was higher (Dyment, Ebers, & Sadovnick, 2004; Ebers, 1996)."

 

There is some exciting research which is looking into the genetic factors and DNA markers which are determined to be involved in MS.  Here is a summary of research which the NMSS has put together.

 

If this doesn't lead to the answer of your question, please feel free to ask again.  Or, actually, please feel free to let us know if there is anything else we can help you with.

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Merely Me, Health Guide
3/19/09 2:44pm

Hi Amanda

 

Are you now concerned that you will get MS too?  There is a genetic component to this disease but they still cannot fully predict who will and who will not get MS based upon genetics alone. 

 

I have just answered a question about genetics which you may find here.

 

What you might do if you are worried is to discuss these risks with your doctor and if you ever begin having any symptoms that concern you, you and your doctor will have a common knowledge of the genetics in your family. 

 

If you have any further questions please don't hesitate to ask.

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By Amanda— Last Modified: 12/26/10, First Published: 03/18/09