Hi Blue,   I'm sorry that you are having such a hard time.  When my Vitamin D levels began to rise, I definitely did begin to feel better.  First thing I noticed was less achiness in my bones.   Like you I take 50,000UL weekly.  However, at first we started with 50,000UL three times each week for a month, switching to weekly afterwards.  I also began to take 2000UL of over the counter Vitamin D2 daily.  Now my levels are barely within the normal range, but we're keeping with the program to try to increase it.   For me, it has taken many months to get my levels to rise.  I hope that supplementation begins to work for you.