Hi Harmony,   I definitely began to feel better as my vitamin D levels began to rise.  I didn't take long to start getting my levels up since my dr had me take the 50,000 pill 3x/week for one month, then I took 1x/week for a month, followed by 1 every other week.  After a few months my levels were still barely within the "normal" range.  So I add over-the-counter vitamin D tablets.    It took about a year to get my levels to where my neurologist and rheumatologist wanted them.  We kept adding different doses of OTC vitamin D supplements.  I currently take 10,000 iu vitamin D(3) capsules daily which I get from an online store.  This is just what "I" need to keep my D levels around 55-60.    Originally, it was my primary doctor who tested my blood levels.  But it is my neurologist and rheumatologist who are on top of checking my levels now and want them to be somewhere between 50-80.   TSH = thyroid stimulating hormone Testing TSH is one method to get a rough estimate of how well your thyroid is functioning.   I hope that you begin to notice a difference quickly.  If you are like me, you might need to combine the prescription D with the OTC vitamin D supplements.  If you've got any questions, please don't hesitate to ask.