Unfortunately, I could have listed ALL of these things and (def not bragging) added a bunch.  I have Raynaud's, which is what causes the sensitivity and change in my fingers and toes.  Change in temperature (or even a sudden change in use (feeling) causes some or all of my fingers on one hand (sometimes one or two toes) to turn bone white, then gradually the blood will start flowing back.  It will then turn bluish to dark purple, and slowly become normal again.  While this happens, there is numbness and tingling. Raynauds does go allow with Autoimmune conditions, which I have numerous.  Too many to list.  I am at this point, being checked AGAIN for Lupus, MS, Scleraderma, vascular disease, etc. The orthopedic doc said the MRI showed small white spots on my brain, but he was considering it as normal, due to my age.  I am 55 years old, but I feel like I am 90.  However, he sent me to a Neuro specialist that thinks "OUTSIDE THE BOX."  The Neuro had the MRI results faxed to him, and because it states that  I have been battling these problems since before 1992. That is the year that I first went to a rheumatologist to try to find out what the problem is.  He diagnosed me with Fibromyalgia and 3 different types of arthritis at that time.   I have read alot of these post and can totally relate to so much of this.  I have been diagnosed with sooo many conditions (most all relate to Autoimmune) and have been under the care of MULTIPLE specialist, but they each will treat me for that particular problem, but NONE can seem to find the actual culprit causing them.  So many doctors don't really know what to do with me (or what to treat at that time) due to over-lapping conditions, that they sometimes just give up on me.  They can run 3 or 4 patients in and out (therefore make more money) by the time we can go over mine.  Thus gives them reason to give me cause to find a different doctor, ie: my PRIMARY physician just did this and I've been with him for almost 5 years...."I am not going to schedule you anymore appts. since you are being taken care of by a number of specialists.  If you need me,...you know where to find me".  Excuse me, but correct me if I'm wrong.  The PRIMARY dr. is supposed to be monitoring my overall healthcare and keeping up with what the other drs. are doing with me.  My orthopedic dr. was concerned about my feet being purple when he walked into the room, and asked who monitors my blood pressure.  I said no one does.  He asked who my primary dr. is now, so I told him that story. I told him the story, and he said....Sounds like he gave up, but I am not going to.  I want to get to the bottom of this and try to help you.  So i guess we'll see what happens with this NEW Neurologist.  So far, my bloodwork came back with B12 deficiency, requiring an injection every week for 1 month, then bi-weekly for 1 month, then stay on it once a month.  Vit D3 was low, so I have to take 2000 mg a day.  Last week I had two Evoke tests done, a VEP (visual) and a BAER (auditory), and this Mon. I will have three MRIs, the neck, mid-back, and lower back.  On Wed. I will have an NCV (Nerve Conductivity Velocity) and EMG (Electromyography) to test the muscles.  OUCH,,,been there done that!!! Hurts so bad, I don't want to go!  I have to take the actual disc of the Brain MRI, because this Neuro dr. wants to read it for himself.  He is concerned about the white spots that the results state are there.  And so it goes, TO BE CONTINUED.........   p.s.  I APOLOGIZE FOR THIS BEING SO EXTREMELY LONG, BUT IT IS UNUSUAL FOR ME TO FIND ANYONE THAT CAN RELATE TO BEING SICK & TIRED ALL THE TIME FOR MANY YEARS NOW, AND STILL NOT KNOW WHATS THE EXACT CAUSE.