Jessica,

I take Rebif. From what I understand, all of the ABCR's have roughly the same efficacy (~30%) so it is really up to you in terms of the number of shots you want and how you want to take them - Subcutaneous (Subcu) or intramuscular (IM). I myself chose Avonex when I was first diagnosed in '97 because it was 1x a week and my husband could give me my shots - IM is a deeper, longer needle. The side effects at first were a pain (chills, flu-like symptoms) but it eventually subsided to just a dull headache the day after the shot. I know others who never could get over the side effects. Going onto Rebif from Avonex, I pretty much had zero side effects but I believe that was because I was basically on the same drug (interferon-A) I know some who have to go through the side effects for a while until their bodies adjust.

I really liked Rebif hen I first started. I really don't like it right now because the shot  is quite painful. There is supposed to be a non-burning version coming out this summer but I have not heard about it being FDA approved. The burning may or may not happen, however all the people I know that take/have taken Rebif had the same burning sensation. I wrote about my Rebif experiences on the Sharepost. Here is my latest post on the subject: http://www.healthcentral.com/multiple-sclerosis/c/6191/30925/sexy

Hope that helps.

Kristin