Tuesday, December 16, 2008 Jen asks

Q: Can you tell me about the benefits of Copaxone?

I hear that Copaxone is different from the other medications for MS.  Can you explain to me how it's different? What is it made of?

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Lisa Emrich, Health Guide
12/16/08 1:16pm

Within the self-injectable medications which attempt to slow down the disease process in MS, Copaxone is that only one which IS NOT a beta interferon medication.  For information on the two types of beta interferon, go here.


Copaxone, originally called Copolymer-1 and now called Glatiramer Acetate, is a random chain (polymer) of amino acids - Glutamic acid, Lysine, Alanine and Tyrosine (hence GLATiramer).  It was originally designed to mimic myelin basic protein and later was thought to act as a decoy for the immune system attacks on the myelin itself.  Now evidence shows that Copaxone converts the body's immune response from the Th1-type (as seen in MS and Rheumatoid Arthritis) to a Th2-type (see this study for more information).


Copaxone is injected daily, whereas the beta interferon drugs (ie. Avonex, Rebif, and Betaseron) are injected weekly, three times a week, or every other day.  Copaxone is not associated with the flu-like side effects which the interferons are, but it does have it's own set of injection site reactions or infrequent postinjection anxiety.


The official page for Copaxone by Teva Neuroscience.


Thank you for your question.  I hope this helps.

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By Jen— Last Modified: 01/13/13, First Published: 12/16/08