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I have been on Avonex for 7 weeks, I have had one injection that I was able to sleep through the side effects.  Other than that I have severe chills and body aches.  My muscles feel like I need to stretch them constantly.  The first dose I will say was much worse but the following doses (except for the one) have not been much better.  I have read many postings about this drug and it seems that it works well for some and not others.   I have seen postings that state they have been on it for several years and the effects have not improved.  I think it is a matter of figuring out a routine that works for you and your body.  I am trying to figure out what I did the one night I slept through and replicate it!  From what I see, drink lots of water, take tylenol, advil, or aleve 1-2 hours before the injection and inject and go to bed immediately or inject 1-2 hours before bed.  That is my summary from the postings I have read thus far.  Good luck, hang in there!