Hello all.  My 38 year old brother in law was diagnosed with Primary Progressive 6 years ago.  It has been very hard to watch a very active man go downhill so rapidly. He was diagnosed with it when he was 32 by a spinal tap.  He has tried many different new experimental drugs but they don't help.  No-one in his family has ever had MS, so it is just amazing how it just hits a person and takes over.  My sister tells me that he gets upset and wants to give up already.  I can't even begin to imagine what it is like for him.  I know what he goes through everyday and the littlest things are so difficult to do, such as making a sandwich.  I try to keep him positive!  I just hope that someday soon, that they will find a cure for his terrible disease.  I wish nothing but the best for all of you and keep optimistic and positive no matter what!  Don't let this disease keep you from doing the things that you love to do.