Hi Steve:  Nice to hear from you.  I am still very careful about what I eat, like eating natural (organic) but so much has changed since 2009.  I got handed a card from a co-worker of my husband's, and all  it said was:  Google LDN, Joseph Wouk.  I did and watched the youtube video that Joe did.  He has the rare kind, progressive relapsing. So I started researching low dose naltrexone, emailing with Joe on Facebook and gave the info I found to my Dr.  and being very open minded, gave me a prescription and I've been on it 1 year.  It does stop PPMS in its tracks!  The fatigue is usually gone in a day. Two websites to check out are: www.lodosenaltrexone.org   and Sammy Jo's   www.ldners.org   If you have any questions she will answer you back.  She did for me.  I found when it came to PPMS, there was really nothing out there and the medical field didn't seem to be interested at all.  I am currently moving from the north of Ontario, back to the Toronto area.  The prescription has to be done at a compounding pharmacy, I use Smith's Pharmacy in Toronto.  Cost is about $55 CDN a month.  It needs to be 4.5 mg to work for PPMS, and not in liquid form but capsule.  You take it just before you go to bed and I found it helps with sleep.   My son who has colitus, takes it as well. Where are you located, if you don't mind me asking? Take care and keep in touch Shirley (aka Sammi)  P.S.  Joe is the son of author Herman Wouk