Hi Steve, I am not a researcher, but have done some googling, and found several medical journal abstracts that make me believe there may be a natural process to at least stop, if not reverse PPMS.    My husband has been dealing with an Fevers of Unknown Origin (FUO) which turns out to be an over active immune system since 1979.  After 2 visits to Mayo and no real understanding of what is going on, he had signs of Vssculitis so the Rhumotologist began treating him for that with the immuno suppressents and such.  That was in 2000, in 2002 a friend told me about Colostrum, we saw an oncologist that said "give it to him, it is mother's milk, it can't hurt" and things have really smoothed out.   So 7 months after I began experiencing this "electrical impulse" going from my neck to leg, I began taking the Colostrum myself.  Finally in August I took time to go to my family Dr. for a physical to tell her about it.  At the appt she mentioned MS and ordered an MRI of my neck to check for a bulging disc.    Duiring the MRI they pulled me out to switch to a "IV contrast" MRI because they saw an "MS plaque" on my spine.  the tech said it did not "light up" as an active MS plaque, and said they'd probalby have me come back ...they did.  The MRI showed more lesions on my brain.  The Neuro said they were "classic MS" lesions and wanted to do a visual evoked response test.  about that time I began taking Epicore - an imunne modulator, much like the Colostrum.  The results of the visual test was as the nurse put it "your optic nerve is stable".  Whatever that may mean.  I wonder if my immune modulators has "deactivated" the demyelinazation to show this.   I am wondering if the immuno modulators, with enzymes, with something to rebuild myelin might be a "cure for MS".  I've tried contacting the lab that did the research for the Epicor their website is www.4greathealth.com .   As I shared I've been seeing medical journal abstracts that talk about disolving scar tissue, and some with MS seem to be having some success with them, modulating the immune system to as I think of it "stop the t cells from munching on the Myelin Shield.  I'm thinking if we can do those 2 things, plus take something or eat a proper diet so the body can rebuild myelin that some may be able to get ahead of the PPMS.    It seems that maybe MS is a tag put on a variety of symptoms, and that may be why some can go years with no setbacks.    It is encouraging to hear you have had such a good 6 years.  If you know of anyone who might be interested in researching or pointing the way for me to research this I'd be appreciative.    My Nuro has not put me on any meds, however I don't know if I would take the steroids as my family physcian had warned me that due to my long term complaints of my vision it has caused blindness and she would not recommend my taking at least one of them.   I apologize for such a long post, but I really think I'm on to something, as so many have done parts of my theory.   Patty