Hi Marmolaid and welcome to Health Central.
I'll gladly chime in with my personal opinion and experience. The very first time I had optic neuritis (in 2000), the neuro-opthamologist gave me options:
1. IV steriods given as out-patient at the hospital, three times a day for three days (that was the protocol at the time rather than all at once)
2. An equal amount of steroids as oral Prednisone for the same period of time.
Both options called for an oral taper over 14 days (think it was 14).
I didn't have insurance at the time and was unable to get "time off" my working schedule. So I opted for the all-oral prednisone route.
1000mg predisone (50mg x 20 pills for 3-5 days, then a taper)
This was VERY TOUGH on my system and I've read other MSers who expressed the same.
The IV route of 1g of Solumedrol for 3-5 days, followed by an oral taper, has been much easier and more effective for me personally. I would absolutely never choose to do that amount of oral Prednisone again. Just my opinion.