My husband was diagnosed in 1992 and managed quite well until he fell in 2005, hitting his head causing a subderal hemotoma. After brain surgeries, his mobility was affected and cognition and memory  to a small degree. Last year after a bout with a couple of UTI's and being bedridden for awhile, his mobility decreased to the point that I must use a hoyer lift to move him. His depression for the past year has been severe and we have tried many different antidepressants with no success. WE are currently on hospice, primarily for the help I need to care for him at home.  He sleeps most of the time and has no interest in anything. He does not want to eat or drink and appears to have totally given up. I am wondering if the MS could be causing his body to shut down, affecting the depression, or what I can expect if things continue in this direction.  Thank you for your help.