Marie,   So sorry to hear that your husband's situation has turned somewhat downward.  Depression is a nasty beast, no matter how mobile or able someone is.  It's certainly possible that the MS itself is affecting his depression.  And perhaps the brain surgeries affected his thinking (mood) as well.   When my grandmother (who did not have MS but did develop dementia) stopped eating, they used a feeding tube with her.  She was sustained this way for quite a while.  At some point when she was no longer conscious much (if not all) of the time, a decision had to be made to stop feedings.  It was a hard decision.   However, there should be steps between his not wanting to eat, using supplements such as Boost or Ensure, and a feeding tube.  Ask the hospice nurses what their experience has been.   On another note, I've heard from some caregivers that their loved one stayed were in hospice for a very long time.  It's good that you have help at home though.    You may want to check out the blog of a dear (online) friend who has primary progressive MS.  AccessDenied-LivingWithMS. The author, Herrad, has been through a lot in the past three years, being confined to bed due to a deep pressure sore was one of those things.  However, she manages to maintain a positivity which is contagious.    Does your husband use the computer to connect with other people living with MS?  I don't know if that would help with his mood, but it is worth a try.  I have found it to be tremendously important and I do not have the physical limitations which many patients do.   Let me ask, how are you doing?  You've been dealing with MS for as many years as your husband.