Hi Lincoln,   I hope that the visit with the new neuroloigist has gone well (or will go well if it hasn't happened yet).  It sounds frustrating that new or worsening symptoms have occurred after the other doctor changed up her medications.  Was she having problems beforehand to need changes?   Regarding the issue of end of life, Ann has provided lots of great information and links to other resources.  I recommend that you check those out if you haven't already.   I'm not sure what to say about approaching the subject of end of life with your sister.  Perhaps it would be good to discuss the possibilities with her new neurologist.  Does someone else (maybe you) have medical power of attorney for your sister?  If someone does, perhaps they should be included on discussions of health in the future and your sister's desires should the time come that she can't speak for herself.   I know that my mother has shared want she would want and not want should the time come.  I appreciate that we've had this discussion well before the time that it may become a reality.  Thinking ahead is usually a good thing even when your faith is strong, espeically when your faith is strong.   Please let us know how the new neuro visit goes.