MS is a very hard disease for the person who has it and the caregivers and loved ones of that person...With a life limiting disease such as MS, the person needs Palliative Care. This is care that does not cure the disease, but lessens the symtoms if possible, and foremost is pain management if the person has chronic pain or even occasional but severe pain. MS pain takes many forms and some of the pain is excruciating, some can be addressed with tylenol. No one with MS should be living in so much pain they are screaming, for there is pain medication available. It can be a scary thing to need strong pain medicine, such as morphine and fentanyl. But the alternative, of living with horrible pain is scary too and it's not fair to the person... MS Pain may require strong pain measures. She should see see a Pain Management Doctor.    Also, non medication pain management exists such as guided imagery, meditation, and massage.    Please please discuss palliative care, pain management, and hospice care as well. Brining in hospice does not necessarily mean the person is dying. Hospice care is a form of palliative care, for people with incurabel illnesses, such as MS, who need extra physical, emotional, and spiritual care.    MS is a horrible disease and you have told how it has ruined her life and the impact on your family...She won't go on forever....MS does kill people. And extreme pain can be one of the signs life is ending.    Her Doctors need to be on her team, and address this pain and address the end of life signs with you both...   The National MS Society has a lot of resources for the families of the person wiht MS, about managing the illness, managing pain, how to talk to doctors to get the help you need, etc......have a look...I have posted this info many times on this website, so look back for my posts or just go to their website and look under "resources"....I hope to hear from you soon, that your wife is not in pain....   It sounds like you are struggling without much outside support and that is a very heavy burden...you need respite care, so that you get a break....the MS society here in the US,  pay for a few days a year, for a nurse's aide to come in and care for the person with MS, so the caregivers get a break...