Hi all, Firstly, I would like to mention few complictions which I believe appear in the final stages of MS. 1- Lose of movement in the limbs which will make you bedridden (Use an Airbed if you are bedriden and change your position every 2 hours to avoid bed sores), 2- Forgetfulness and Thinking of things that happend long ago like happening now. 3- Difficulty in swallowing food or water. 4- Lose of proper diet leads to several complications like low sodium levels lowering Blood pressure and if diabetic leads to fluctuated sugar levels. 5- Once swallowing food becomes difficult and if you force- food may enter the trachea leading into lungs rather entering esophagus leading into stomach. 6- This will lead to blockage of the lung airways and makes it difficult to breath. 7- At this point you may need a Trachestomy done, to clear of the secretions form your trachea and clear you airways constantly, to help you breathe. 8- Urinary tract infections may arise if you lost sense of urination.   These are few complications I saw personally in my grandmom in the order who is suffering with MS and is now in her final stages. To know more about our story read further.    I am feeling really sad and awful after reading all the  material and stories of the patients and their families suffering with MS. I would like to share my story with you all, since this very different from all yours and cannot stop myself sharing it. The reason I said "Awful" is because I have my grandmom diagnosed with MS few weks ago. She is 65 y/o and has been having all the symptoms mentioned in the various MS related sites and even in this blog. She was facing these symptoms since approximately 8 years and was taken to several well-known doctors (including neurologists) in the city (Luckily, this city is not in the United states. I am from India) and none could have diagnosed it. Every one told she had some sought of vitamin deficiency or some other lesion in her spinal cord which is pressing against one of her arteries, which is not letting the blood to circulate into her lower limbs and this why she is having those kind of flare-ups. 8 years ago I was 18 and I had no knowledge about MS, But I was constantly thinking that there will be a cure for her illness and I will find it out if the doctors cannot. I am 24 now and currently am an investigator in breast cancer. I always had this thought about my grand mom since I was away from her and started researching on her symptoms. With the help of my colleague and a dear friend, unfortunately, whose mother is also suffering with MS, I figured it out that my grandmom may be having MS. By the time I realised the facts and have done my research my grandmom fell sick. I came back home immediately and have been taking care of her since last month. She is bedridden and cannot swallow her food nor move any of her limbs. She was the one who raised me since my childhood, as my mom was busy with her work, and now she hardly recogninzes me when I returned for her. I am feeling very bad as we were not able to diagnose her problem properly earlier. This lead to many misunderstandings between my grandmom and my family members. At times we even believed she was lying about her pains and flare-up's since none of the doctors really told if there was any serious problem. They would always leave us guessing saying this was a rare situation. I am feeling sopo sorry for my grandmom right now and I cannot stop tears rolling down my eyes. She is in ICU right now while i'm writing this with Ryles tube feeding, Trachestomy done to remove the secretions from her lungs, Urine collector, and a Big bed sore which needed surgery to remove the necrotic tissue. She is suffering with infections at the bed sore wound site , in her lungs, and in the urinary tract. She cannot utter a word nor recognize any of the family members. she would  only give a nod for anything you ask. She is diabetic so the infections keep coming and the wound is taking really long to heal. We have started Sub-atmospheric pressure therapy for the wound since we heard it will help in faster healing and avoids infections. Doctors said that they cannot do anything at this stage. Although there are some medications like Interferons we could use, we are not in a position to afford it. But, I am still strong and i'm not loosing any hope. We treated her with Immunoglobulin therapy a while ago on my request and it helped my grandmom to recover a very little. She atleast recognized me after the therapy. But still it did not improve any of her physical condition. We are planning to get her discharged from the hospital and give care at our home. I hope she will get better, BUt I don't know what to do when the condition gets worse. I have no clue, all my family is in a helpless situation. I am feeling really awful about it. I Know i'm writing too much here but i'm not able to control my emotions and can't stop writing about this. I love her soo much...if it was'nt her I would'nt have anyone who encouraged me by saying I could achieve anything in this world if I have the real concentration over things. she is a strong person and even after soo much suffering she would not utter a word or show the pain. I am sorry for not able to do anything to make her condition better. But I will not stop having hopes. I will do whatever it takes to make her feel better until her last breath.    Navin.