I have had muscle pain and weakness in BOTH legs for the past 10 months with no diagnosis. I also get muscle weakness in my arms occasionally, but my legs are always affected. The weakness is in my thighs, knees, and calves. The pain seems to be mainly in my calves. Many days my legs feel like they're going to give out on me. Some nights while sleeping, my leg(s) and/or arm(s) will totally go numb. I've had a brain MRI, EMG and nerve conduction tests, Lyme Disease blood work, and everything comes back fine. Cervical MRI revealed two protruding discs and Lumbar MRI revealed a herniated disc at L5-S1 for which I had an epidural injection prior to the leg pain/weakness starting. About a month before the muscle weakness/pain started I stopped taking my antidepressant abruptly per my doctor's advice (I realize now I should have slowly weaned). I did endure 2 weeks of horrible withdrawal symptoms. I'm at a loss as to what I should do and some days are so difficult with the pain and weakness. Could I have Lyme Disease even though all my tests were negative? My son had Lyme Disease this year and I wonder if I should just try taking an antibiotic. I just want to feel normal again. Thanks for your help!