Hi Kathy,   Sorry to hear that you're having a flare-up right now.  But fortunately, Solumedrol (often called IVSM) is very effective in speeding the resolution of a relapse.   What it does is reduce the inflammation in the central nervous system (CNS) and help to close the blood-brain-barrier which allows the attack in the CNS.   I've done the IVSM treatment (each time over 5 days) three times so far.  Here are my thoughts and tips:   * During the IV drip, you will experience a yucky metallic taste in your mouth.  Suck on mints and hard candies to mask this. * If, after the first day, you experience a big headache, ask that the drip be slowed down for the other days.  I always have to stretch the drip from 45-60 minutes to 90 minutes. * You will very likely experience excess stomach acid.  Be proactive in protecting your stomach and use an acid reducer such as Zantac.  My neuro recommends this for everybody. * Steroids will deplete potassium in your body and cause you to retain water.  Each potassium rich food and avoid salty high-sodium foods such as potato chips. * Steroids tend to make you very hungry.  Try not to eat everything in the fridge. * IVSM is such a high-dose of steroids that it messes with sleep and can cause insomnia.  I often felt like my heart would be pounding out of my chest.  Discuss using a sleep aid such as Ambien or Rozerem just for the few days of the IVSM treatment. * You might experience a burst of energy.  Enjoy a clean house but don't over do it. * It is recommended to use a Prednisone taper after the Solumedrol treatments.  That is similar to what Merely Me used alone to treat a relapse. * Steroids can increase anxiety and/or depression.  If you experience these, don't wait to talk to your doctor. * Lastly, while on the steroids (including the taper), you might be extra emotional.  This is completely normal.  My advice - do not make any major decisions.   At my first Solumedrol infusion, another patient in the clinic smiled at me when he described that IVSM was like PMS in a liquid bag.  I think he was onto something there.   Good luck, and please do share how this goes for you.