What do you think about the 4AP drug, I live in NC, and I want to try it, do you think that I will be able to. Is it available in NC yet?
There is a far amount of anecdotal evidence that 4-AP (4-aminopyridine) can be an effective drug to address symptoms of MS. It works by blocking potassium-ion channels in demyelinated areas of nerves, in effect helping to boost the electric signal.
The drug 4-AP must be obtained from a compounding pharmacy as it is not available commercially. There is a drug company, Acorda Therapeutics, who has completed trials for their version called Fampridine-SR. They estimate that it may receive FDA approval sometime next year. Fampridine-SR is considered to be safer than compounded 4-AP.
Some neurologists have reservations in prescribing 4-AP; some are not familiar with it beyond the increased risk of seizures; and some have several patients who take it and are doing really well.
There is a group of patients who are actively discussing their experiences with 4-AP. As I've never tried it, I'd recommend that you read their stories at Patients Like Me. One patient started a journal and others have jumped in. The journal is now 68 pages long and full of information.
If you do talk about it with your neurologist and give it a try, I encourage you to share your experience with us in your Shareposts (which I have enjoyed reading already).
I have been taking 4ap for left leg weakness/Lyme disease for 10 days at 2.5 mgs with lunch once a day. I took 5mg. to start and had a cascade of side effects that were intolerable. First I got dizzy, then I got full of rage although nothing was happening that should make me angry and my thinking (usually crisp) got very confused to where I could not understand the newspaper....But my left leg got very strong. This lasted maybe 6-8 hours. Now I am trying half that much and going for a nap after lunch in order to sleep through the rage which is less than on the 5 mg. dose, as is the leg strength. When I get up am still woozy and not understanding so well but I have a much stronger better afternoon and evening.. I have my eye on the prize and hope I can work with this.
Septra also made my left leg stronger but had unpleasant mental effects of fatigue and depression and I worried about kidney problems long term.