Baclofen does work but through time i am on a cocktail of meds which include baclofen, neurontin, klonapin and tramadol( when needed). The klonapin and baclofin help the spasms and the twitches I get(large twitches) and neurontin is good for nerve pain. Does anyone get the type of pain that makes you want to squeeze your legs or arm? Also has anyone lost muscle mass. I have atropy even in my right rectus(abdominal)muscle seen on MRI. I didn't know with my MS If I would lose muscle. My latest problems have been for the 3 weeks now. I hope it doesn't last long!!! I hate the heat. Also anyone with migraines?