I feel like there are vices connected to my legs squeezing all the time! Yes, I have muscle loss! It has helped ease my mind a little reading all these comments. I was not aware that my leg problems were MS related. I was diganosed (Formally) in September 2010. I have been going thru the possible MS the Neurologist called it "Difinitve MS" for years. I am 45, and have been going thru this since I was 18! It took that long to get the diagnosis. Today the Neurologist and Rheumatologist do not agree, one thinks I have MS and Lupus, the other thinks it is only MS. It can be very discouraging! I have a question. Does anyone else have peripheral edema? I have had edema in both legs, abd., and face for years. I had a Nephrologist tell me my failing kidneys were due to the fluid pills I was on for the edema. 1 and 1/2 years after being off the diuretics, I am still experiencing edema, now having kidney problems again! Any advise??