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Hi, I have MS as well and about 8:30 I feel the tightness in my legs. If I get up and walk around I have relief - as soon as I lay down it starts again. Last night was an all nighter.... my dog is probably sleeping all day - while I am at work!   I find tylenol arthritis pain relief does help it during the walking around parts of the day... but at night I take a sleeping aide or I do not sleep.   Lisa
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