I have been taking Synthroid for over a year now. In addition to that I had a hysterectomy 4 years ago. So mix the Synthroid with the Estrogen and turning forty and the recipe is a flop. It has taken me 18 months to lose 10 pounds. I have 40 more to lose, but at this rate it will take me 6 years to lose it. I have taken the nutrition classes, exercise classes, and follow a strict diet. I exercise 45-85 minutes 5 days a week. The time is split between muscle training and cardio. But now I am getting depressed about the whole situation. I don't know where to turn to or do now.