Zonisamide. Zonisamide (Zonegran) is an anti-seizure agent that is also being investigated for weight loss. In one study, patients who took it lost more weight than those on placebo. Zonisamide increases the risk for kidney stones, which can be reduced with increased fluid intake and citrate. It has also been associated with reduced sweating and a sudden rise in body temperature, especially in hot weather. Other side effects include dizziness, forgetfulness, headache, and nausea.
Topirimate. Topirimate (Topamax) is another anti-seizure medication being investigated for weight reduction. Three clinical trials have reported that patients given topirimate lost more weight than those receiving placebo. Weight loss was sustained for up to 1 year. The drug is also being studied for binge-eating disorders associated with obesity.
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