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Researchers at the Fisher Center for Alzheimer’s Disease Research at The Rockefeller University have published the results of their recent study, which showed that non-steroidal anti-inflammatory drugs (NSAIDs) reduced the effectiveness of selective serotonin reuptake inhibitor (SSRI) antidepressants.
NSAIDs include over-the-counter medications like ibuprofen, aspirin and naproxen as well as prescriptions drugs such as Celebrex, Daypro, diclofenac, etodolac, ketoprofen, meloxicam, Mobic, Naprosyn, Relafen, Toradol, Voltaren, etc.
You may be wondering what this study has to do with chronic pain. Antidepressants are sometimes prescribed as a treatment for chronic pain because they help increase serotonin, which is important for pain modulation. If NSAIDs prevent antidepressants from being effective for depression, they may also interfere with the ability of antidepressants to reduce pain. Study Design and Results Scientists first tested their theory on mice...
December 28, 1992, marked a new era for Migraine sufferers with FDA approval of injectable Imitrex (sumatriptan). Imitrex was the first Migraine abortive triptan medication, a class of medications that many Migraineurs would come to call “miracle drugs.” Imitrex tablets were approved by the FDA in 1995. Since then, six more triptans have entered the market – Maxalt , Zomig , Amerge , Axert , Frova , and Relpax . Although triptans are a marked improvement over previous treatment options, many Migraineurs have not been fully satisfied with their results. Some do not achieve full relief from triptans, and the recurrence of Migraines within 24 hours of the first dose has been common. With the patents on sumatriptan nearing their expiration, both generics of the current forms – injections, tablets, and nasal spray – and other medications containing sumatriptan are now in development and testing. The results involving Trexima, one such medication that is a com...
I am a bit confused about MOH. Can naproxen sodium (Aleve, etc) cause it? I don't see it listed among the usual suspects. I take naproxen as my first line defense against my chronic daily migraines. It is, thankfully, sometimes effective and I'd hate to give it up. Thanks. Elizabeth.
NSAIDs such as naproxen sodium should not be taken daily. A recent study confirmed that:
NSAIDs were actually associated with a decreased risk of transformed Migraine ONLY for Migraineurs with fewer than 10 - 14 Migraine days per month. This would serve to confirm that NSAID use should be restricted to no more than two or three days per week and should NOT be used for Migraine prevention.
For more information on this, please see Medication Overuse Headache - When the Remedy Backfires .
It's entirely possible that daily use of naproxen sodium is making things worse for you. The better option is to work with your doctor t...
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