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Long term use of the painkiller ibuprofen when taken for more than five years has been found to decrease the risk of Alzheimer's disease by 40 percent. Published in the
Journal of Neurology, this large scale study demonstrated that the type of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) was important in risk reduction. They found some NSAIDs less effective than others. Indomethacine only reduced risk of Alzheimer's by 25 pecent and Pfizer's Celebrex and Celecox had no effect at all.
The newly published study looks at work carried out by researchers from Boston University School of Medicine, Boston University School of Public Health and Bedford Veterans Affairs Medical center. It involved over 49,000 veterans aged 55 years and older.
The ibuprofen group of medicines include brand names such as Advil, Motrin and Nurofen. NSAIDs are one of the most widely used drugs for pain relief of non-serious arthritic conditions, for rheumatic or muscular pain, backache...
Acute inflammation is the body's natural response to tissue damage. Its purpose is to defend the body against harmful substances, dispose of dead or dying tissue and to promote the renewal of normal tissue. Therefore, inflammation is normal if we are ill from a virus or bacterial infection or we injure ourselves.
However, chronic inflammation is different. Chronic inflammation is involved in many autoimmune diseases including rheumatoid arthritis, allergies and even some cancers. Mounting evidence is now showing that chronic inflammation is also likely part of the Alzheimer’s puzzle.
In 2010, Karl Herrup, the chair of the Department of Cell Biology and Neuroscience at Rutgers University, wrote that he believes "...three key steps…are needed for an individual to progress …to the full spectrum of Alzheimer’s clinical symptoms: an initiating injury that is probably vascular in nature; an inflammatory response that is both chronic and unique to...
More and more research pinpoints inflammation as a root cause of type 2 diabetes. Being overweight makes it harder for us to control our diabetes, but that can't be what causes it. Since a lot more people are overweight or obese than have diabetes, weight alone can't lead to diabetes. No one ever demonstrated that obesity causes diabetes or even insulin resistance. In my most recent book, Losing Weight with Your Diabetes Medication , I speculated that essentially it might be the other way around: That what makes so many of us overweight could be insulin resistance or impaired beta cells.
Type 2 diabetes generally results from the combination of impaired beta cell function and insulin resistance acting on susceptible genes. Why then is there such a large overlap between being heavy and type 2 diabetes? When our beta cells don't function properly, we are likely to get diabetes, Endocrinologist Daniel Porte Jr., M.D., who is now associated with the VA San Diego Health Care System...
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