More and more of what I read about diabetes implicates inflammation. So
when Dr. Michael Jaff told me about its role in peripheral arterial
disease (PAD) I took the opportunity to delve into what he could tell
me about both inflammation and PAD. Dr. Jaff is the medical director of the Vascular Diagnostic Laboratory at
Massachusetts General Hospital and a specialist in treating PAD. My previous article here reported on our discussion of the role of exercise in preventing PAD, which is one of the complications of diabetes. Inflammation is a broad term. It includes everything from peritoneal disease to muscle soreness and plaque in our arteries. "We
all think about
inflammation as in inflamed joints after we exercise," Dr. Jaff began.
"Things like that. But there is a fairly common pathway for all forms
of inflammation." We have certain cells that
cause inflammation, and they are white blood cells. Most people think of
white blood cells as those that fight off infection, but in fact white
We know that exercise somehow reduces our risk of heart disease , the most common complication of diabetes . But we really haven’t known how. Now for the first time a new study offers an explanation of how it works. The study, “Aerobic Exercise Attenuates Inductible TNF Production in Humans” will appear in a forthcoming issue of The Journal of Applied Physiology . The lead author, Richard Sloan, professor of behavioral medicine at the Columbia University Medical Center, kindly sent me a pre-print of the article. Just the abstract is available online. That’s a terribly technical title. Exercise done with oxygen – referring to the use of oxygen in a muscle’s energy-generating process – is aerobic. Many types of exercise are aerobic. Generally, we do aerobic exercise at a low to moderate level of intensity for quite a while. For example, when we run at a moderate pace it is aerobic, but sprinting isn’t. But in this study Dr. Sloan and his associa...
Acute inflammation is the body's natural response to tissue damage. Its purpose is to defend the body against harmful substances, dispose of dead or dying tissue and to promote the renewal of normal tissue. Therefore, inflammation is normal if we are ill from a virus or bacterial infection or we injure ourselves.
However, chronic inflammation is different. Chronic inflammation is involved in many autoimmune diseases including rheumatoid arthritis, allergies and even some cancers. Mounting evidence is now showing that chronic inflammation is also likely part of the Alzheimer’s puzzle.
In 2010, Karl Herrup, the chair of the Department of Cell Biology and Neuroscience at Rutgers University, wrote that he believes "...three key steps…are needed for an individual to progress …to the full spectrum of Alzheimer’s clinical symptoms: an initiating injury that is probably vascular in nature; an inflammatory response that is both chronic and unique to...
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