Long term use of the painkiller ibuprofen when taken for more than five years has been found to decrease the risk of Alzheimer's disease by 40 percent. Published in the
Journal of Neurology, this large scale study demonstrated that the type of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) was important in risk reduction. They found some NSAIDs less effective than others. Indomethacine only reduced risk of Alzheimer's by 25 pecent and Pfizer's Celebrex and Celecox had no effect at all.
The newly published study looks at work carried out by researchers from Boston University School of Medicine, Boston University School of Public Health and Bedford Veterans Affairs Medical center. It involved over 49,000 veterans aged 55 years and older.
The ibuprofen group of medicines include brand names such as Advil, Motrin and Nurofen. NSAIDs are one of the most widely used drugs for pain relief of non-serious arthritic conditions, for rheumatic or muscular pain, backache...
More and more of what I read about diabetes implicates inflammation. So
when Dr. Michael Jaff told me about its role in peripheral arterial
disease (PAD) I took the opportunity to delve into what he could tell
me about both inflammation and PAD. Dr. Jaff is the medical director of the Vascular Diagnostic Laboratory at
Massachusetts General Hospital and a specialist in treating PAD. My previous article here reported on our discussion of the role of exercise in preventing PAD, which is one of the complications of diabetes. Inflammation is a broad term. It includes everything from peritoneal disease to muscle soreness and plaque in our arteries. "We
all think about
inflammation as in inflamed joints after we exercise," Dr. Jaff began.
"Things like that. But there is a fairly common pathway for all forms
of inflammation." We have certain cells that
cause inflammation, and they are white blood cells. Most people think of
white blood cells as those that fight off infection, but in fact white
We know that exercise somehow reduces our risk of heart disease , the most common complication of diabetes . But we really haven’t known how. Now for the first time a new study offers an explanation of how it works. The study, “Aerobic Exercise Attenuates Inductible TNF Production in Humans” will appear in a forthcoming issue of The Journal of Applied Physiology . The lead author, Richard Sloan, professor of behavioral medicine at the Columbia University Medical Center, kindly sent me a pre-print of the article. Just the abstract is available online. That’s a terribly technical title. Exercise done with oxygen – referring to the use of oxygen in a muscle’s energy-generating process – is aerobic. Many types of exercise are aerobic. Generally, we do aerobic exercise at a low to moderate level of intensity for quite a while. For example, when we run at a moderate pace it is aerobic, but sprinting isn’t. But in this study Dr. Sloan and his associa...
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