Merck, the manufacturer of Vioxx recently announced that preliminary analyses of its MEDAL (Multinational Etoricoxib and Diclofenac Arthritis Long-Term Program), show that patients with osteoarthritis and rheumatoid arthritis have similar cardiovascular outcomes between its experimental COX-2 inhibitor drug, Arcoxia, and diclofenac, a traditional nonsteroidal anti-inflammatory drug (NSAID). Merck is developing Arcoxia as the successor to Vioxx.
The MEDAL program is a group of three studies that...
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From Our Sources
Scientists discover why COX-2 inhibitors are bad for the heart...
U.S. and Canadian researchers have discovered why COX-2 inhibitors like Celebrex cause blood-pressure and heart problems. The researchers also found... Read more »
Data on COX-2 inhibitor Arcoxia gives good--and bad--news
A new study on the COX-2 inhibitor Arcoxia is intensifying worries about the drug's safety. Though researchers found that the new drug had similar... Read more »
Clinical trial: Efficacy and safety of investigational COX-2 i...
GlaxoSmithKline is conducting a clinical trial to see if its investigational drug, a COX-2 inhibitor called GW406381, is safe and effective. This... Read more »
Clinical trial: COX-2 inhibitor study in patients with RA
This is a study to find out if an investigational drug called GW406381 can help people with rheumatoid arthritis. This international study is... Read more »
Study points to cause of COX-2's heart risks
Scientists believe they've discovered what causes COX-2 inhibitors such as Vioxx and Celebrex to boost users' heart risks. Researchers working with... Read more »
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