how side effects related to bisphosphonates can be reduced with more additional effects? is there any drug which can reduce side effects of bisphophonstes?
what are the future drugs for osteoporosis? which are more effect and safe?
please suggest some new and safe combination for osteoporosis treatmen?
Hi deepak, welcome and thanks for your question. You asked how to reduce side effects of bisphosphonates, but we would need to know which side effects you are referring to. If you are having stomach problems with the med there are things you can take to alleviate these, but your Dr. would have to determine which to prescribe.
If you are referring to bone or joint pain, then typically they prescribe an over-the-counter pain med or anti-inflammatory for that.
There are several new drugs in the pipeline, but they haven't been approved yet by the FDA. All medications have their own side effects and I don't know of a single drug/supplement that doesn't have some side effects.
Strontium Citrate is an over-the-counter supplement that is used for osteoporosis which you could look into. See Phyllis' SharePost on the Home page about this option. There's also Fosteum, which you can read about at this article. Fosteum has isoflavone isolated from soy, so if you have any allergies to soy or have had cancer, you wouldn't be able to take this since we don't know how soy reacts with cancer. Ask your Dr. if he or she has any suggestions that could help you.
I hope this helps, and if you have another question just post again.
Hi deepak, the only other meds I can think of are mentioned in my original reply, have you had a chance to read about them yet? The pipeline drug that hasn't been approved yet is Denosumab if you want to read about it here's a NEJM article on it. Keep in mind that it's NOT available yet or approved, but we may hear something favorable by Oct 2009. Here's a study done on it if you aren't familiar with it. Check out these three possible suggestions to see what you think (Fosteum, Strontium Citrate (US available) Strontium Ranelate (EU available) and Denosumab (not approved yet in US). There's also the non bisphosphonate meds like Forteo see the previous link from the Cleveland Clinic, Miacalcin (Calcitonin), Evista (women only) and HRT (women only).
Good luck in your search!!
hi pam,
thanks for your answers. it is really helping me alot to undstand beter about osteoporosis.
i hav few more question, mentioned below:
1. can you suggest me which bisphosphonate is best among all bisphosphonates based on side effects, frequency of dosing.
2.out of all strontium combinations lik strontium citrate, ranelate, gluconate, malonate etc ,which is beter? please suggest me that.
3. what is the reason for strontium side effects? why such high dose and long duration of treatment is required?
4.what is the mechanism of action of b blockers in bone remodelling.
if you hav any literature related to all above questions please send me that also.
with regards
deepak
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respected mam,
thanks for your reply.
The adverse events of the nitrogen-containing bisphosphonates are reviewed. Oral bisphosphonates (alendronate, risedronate and ibandronate), mainly used for the treatment of osteoporosis, have been associated with adverse events from the upper gastrointestinal tract, acute phase response, hypocalcaemia and secondary hyperparathyroidism, musculoskeletal pain, osteonecrosis of the jaw and ocular events. Intravenous bisphosphonates (pamidronate, ibandronate and zoledronic acid), used in oncology and for the treatment of osteoporosis, have been associated with all the above adverse events, except those from the upper gastrointestinal tract. Moreover, pamidronate and zoledronic acid have been associated with renal toxicity. Association of bisphosphonates with atrial fibrillation and atypical fractures of the femoral diaphysis remains uncertain. There are a few case reports relating bisphosphonates to cutaneous reactions, oral ulcerations, hepatitis and esophageal cancer. Generally, intravenous are more potent than oral bisphosphonates and the frequency and severity of some of the bisphosphonate- associated adverse events are dose and potency dependent. use of three oral bisphosphonates nearly triples the
risk of developing bone necrosis,a condition that can lead to disfigurement
and incapacitating pain, say researchers in an article in the Jan. 15 online issue of
The Journal of Rheumatology.Researchers at University of British Columbia (UBC) and
Vancouver Coastal Health Research Institute (VCHRI) conducted an epidemiologic study of bone necrosis and bisphosphonates taken by women to help
prevent bone fractures due to osteoporosis.This study of 87,837
elderly patients was the first to explore the link between bone necrosis and the bisphosphonates alendronate, etidronate and risedronate.
so can u suggest me that how i can minimise these side effects? is there any combination which i can try with bisphophonates therapy to reduce all these side effects and get good additive effect i.e beter improvement in bone parameters.
or can u suggest me any new combinations which has not been tried before for osteoporosis but may be very effective and safe for treatment as compared to present therapies. i am a research student so i can test that newer combination on osteoporotic rat models and find out the results and inform you about it. so i will be very thankful to you if you suggest me some newer effective and safer combinations which has not been tried till date but can be useful in future.
with regards
deepak