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Hi Miss P,   Thank you for your questions! Very little is known about the effects of Fosamax on pregnancy. Fosamax has only been studied in post-menopausal women, so it is unknown whether it could affect your chance of conceiving at a later point in time. Similarly, there have been no controlled studies using Fosamax or any similar drugs in pregnant women. The benefits and possible risks of taking Fosamax should be carefully weighed before deciding on a course of action. Since the effects of Fosamax during pregnancy are unknown, this is something you would have to seriously consider and discuss with your doctor.   There is are IV medications available for osteoporosis. Reclast, Zometa, and Boniva are all indicated for the treatment of osteoporosis in postmenopausal women. Again, these medications haven't been studied in pregnant women, but Zometa and Reclast have been shown to cause problems in animal studies. The IV medications are associated with less irritation to the esophagus, as you had suggested.   There are no reported drug interactions between bisphosphonates and Remicade.   I hope I answered all your question!! Best of luck, Casey