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Men Spared Side Effect From Pain Reliever

Posting Date: 11/07/2005

Q. I was surprised to hear that taking acetaminophen daily might lead to elevated blood pressure. Even though I eat a low-fat, vegetarian diet I am stuck with the family curse?high blood pressure. I take extra-strength pain relievers containing acetaminophen several times a week.

A. Researchers reported in the journal Hypertension (Sept. 2005) that women who regularly rely on more than 500 mg of acetaminophen daily almost doubled their risk of developing high blood pressure. Although aspirin was not implicated, other nonsteroidal anti-inflammatory drugs like ibuprofen were associated with higher blood pressure in this study.

The investigators concluded ?Because acetaminophen and nonsteroidal anti-inflammatory drugs are commonly used, they may contribute to the high prevalence of hypertension in the United States.?

Men may be less susceptible, however. A large study of male doctors found no connection between pain reliever use and high blood pressure (Archives of Internal Medicine, Sept. 12, 2005).

Q. I take alendronate (Fosamax) to keep my bones strong. I am concerned about the possibility this drug could cause osteonecrosis. What can you tell me?

A. Osteonecrosis of the jaw (death of the jaw bone) has been linked to a class of drugs called bisphosphonates that includes Fosamax. Although quite rare, this complication appears more likely when Aredia or Zometa are given intravenously to treat cancer patients. A few cases have been associated with taking Fosamax or Actonel for osteoporosis treatment. Tooth extraction seems to trigger this serious condition and dentists are being urged to preserve teeth whenever possible.

Q. Sometimes I get terrible cramps in my feet and lower legs at night. When they occur, I get up, walk around and yell a lot. If I take a couple swigs of tonic water, that may help.