People's Pharmacy

Pravachol

Generic Name:pravastatin

Revised:4/1/2000

Table of Contents

Side Effects and Interactions

Pravachol has relatively few side effects and most people tolerate it well.

Some adverse reactions that may occur include nausea, flatulence, constipation, diarrhea, stomachache, fatigue, headache and skin rash.

Less common complications include dizziness, muscle pain, change in the sense of taste, insomnia, and numbness or tingling of the hands or feet.

Muscle aches or weakness could be a sign of a serious reaction called rhabdomyolysis or myopathy, and call for a test of kidney function.
Kidney failure might be the outcome of untreated myopathy. Report any symptoms to your physician promptly.

The danger of rhabdomyolysis or myopathy is increased when Mevacor is combined with certain other drugs.

Troleandomycin or erythromycin antibiotics such as E.E.S., E-Mycin, Erythrocin or PCE have been involved in several cases.

The new antibiotics Biaxin and Zithromax belong to the same class of drugs, but it is not clear if they have a potential for such an interaction.

Because Pravachol is in the same class as Mevacor, this interaction may pose hazards with Pravachol as well.

When Pravachol is combined with other cholesterol-lowering medicines such as Lopid or niacin be alert for muscle pain, weakness, and kidney damage, as rhabdomyolysis may be more common in this situation.

The transplant drug Sandimmune might also increase the risk of this dangerous reaction.

Pravachol may also increase the action of the blood thinner Coumadin; prothrombin time should be closely monitored.

Questran or Colestid may reduce the absorption of Pravachol if they are given at the same time.

Tagamet also appears to interact with Pravachol.

Check with your physician and pharmacist to make sure Pravachol is safe in combination with any other drug you may take.