People's Pharmacy

Prempro

Generic Name:conjugated estrogens / medroxyprogesterone

Other Brand Names: Premphase

Revised:4/1/2000

Table of Contents

Special Precautions

There are a number of situations where Premphase may be inappropriate.

Pregnant women should not use this medication, as it could affect the fetus.

Women with a history of breast cancer or other malignant disease susceptible to estrogen are generally advised to avoid this hormone.

Blood clotting disorders such as thrombophlebitis are also a reason to be wary of Prempro.

Prolonged use of postmenopausal estrogen has been controversial because it increases the risk of endometrial carcinoma or cancer of the uterine lining.

Medroxyprogesterone, as supplied in Premphase, counteracts this danger to a large extent.

Vaginal bleeding could be an early warning sign of cancer, however, and requires immediate medical attention.

Medroxyprogesterone does not appear to be protective against the increased risk of breast cancer. Women with a strong family history of breast cancer will want to discuss this issue with their doctor.