People's Pharmacy

Diflucan

Generic Name:fluconazole

Revised:4/1/2000

Table of Contents

Side Effects and Interactions

Side effects that have been reported with Diflucan include nausea, vomiting, diarrhea, indigestion, and stomach pain.

Liver enzymes occasionally become elevated and should be monitored.

Other side effects may include headache, dizziness upon standing up suddenly, rash, and changes in taste.

Serious allergic reactions including trouble breathing and shock (anaphylaxis) have occurred rarely. Report any symptoms to the physician promptly.

Although Diflucan works by inhibiting CYP 450 enzymes in fungus, CYP 450 enzymes in mammals, including humans, seem less affected.

An interaction study found that Diflucan has no effect on blood levels of Seldane.

Diflucan does, however, interact with certain other medications: Coumadin, oral blood-sugar-lowering medicines such as DiaBeta, theophylline, and the transplant drugs cyclosporine and tacrolimus. Such combinations should be avoided whenever possible. Careful monitoring is required if both drugs are needed.

Women on birth control pills were given Diflucan in studies. Although most women had higher blood levels of the components of The Pill, some had decreases up to 47 percent of ethinyl estradiol and 33 percent of levonorgestrel. It is not known whether this could compromise contraceptive efficacy.

Diflucan interacts with AZT (zidovudine), Dilantin, hydrochlorothiazide and rifampin.

Check with your physician and pharmacist to make sure this medicine is safe in combination with any other drug you may take.