People's Pharmacy

Dilantin

Generic Name:phenytoin

Revised:4/1/2000

Table of Contents

Side Effects and Interactions

Dilantin can cause a number of side effects which are more common at higher doses.

Symptoms to be alert for include slurred speech, confusion, clumsiness, tremor, poor coordination, dizziness, drowsiness, uncontrollable eye movements, blurred vision, muscle twitching, insomnia, headaches, nervousness and hyperactivity.

If these adverse reactions do not disappear within a few weeks of starting therapy contact your physician promptly and request a blood test.

If you develop a skin rash call your doctor immediately. This side effect usually calls for the discontinuation of the medicine, though this may require a gradual tapering of the dose and the substitution of another drug.

Other less common side effects include chest pain, nausea, diarrhea or constipation, water retention, numbness or tingling of hands and feet, hair loss, fever, blood changes, weight gain, and liver problems.

Some women note unwanted hair growth on their faces or bodies. Report any symptoms to your physician promptly.

Many people who take Dilantin for long periods of time experience overgrowth of the gums. In this case good dental hygiene is especially important. Frequent dental visits are advisable.

A large number of over-the-counter and prescription medications may interact with Dilantin in a dangerous way.

This anticonvulsant can interfere with the transplant drug Sandimmune, increasing the risk of rejection.

Certain other anticonvulsants may increase Dilantin's toxicity, as may Prozac or related antidepressants.

Some drugs, such as theophylline or tuberculosis drugs, can reduce the effectiveness of Dilantin and make people more vulnerable to seizures.

In addition, Dilantin can interfere with the effectiveness of many other medications, including doxycycline, theophylline, birth control pills and the heart medicine Cordarone.

Other drugs that interact with Dilantin include alcohol, calcium-based antacids, pain relievers containing acetaminophen, folic acid, quinidine heart drugs, the blood thinner Coumadin, certain antidepressants and the ulcer medicines Tagamet and Prilosec.

Do not take any other medication without first checking with your physician and pharmacist.