People's Pharmacy

Serzone

Generic Name:nefazodone

Revised:4/1/2000

Table of Contents

Special Precautions

Serzone can interact in very dangerous ways with many other medications. Please check with a physician and pharmacist before starting Serzone if you are taking any other medications, or if you are taking Serzone and any other drug is added to the mix.

Some people experience low blood pressure while taking Serzone. This may be especially problematical when getting out of bed or standing suddenly (orthostatic hypotension). Dizziness or fainting may result.

This adverse effect is especially dangerous for people with cardiovascular conditions such as heart disease or a history of heart attack or stroke.

Anyone who is dehydrated or taking blood pressure medicine may also be at greater risk of this complication.

Patients with liver problems, irregular heart rhythms, or a history of seizures require careful monitoring while they are taking Serzone.

Older people and women may be more sensitive to Serzone. Dosage adjustments may be necessary, especially for older women.

Please point this situation out to your physician if you fit either category.

Before a woman becomes pregnant she should discuss the safety of Serzone with a physician beforehand.

People with a history of suicide attempts must also be extremely vigilant. Family members must help monitor people on Serzone for suicidal thoughts or self-destructive behaviors. The doctor must be notified immediately in such cases.

It often takes antidepressant medication several weeks to produce a noticeable improvement in mood. Patients and family members need to give Serzone a fair trial period to determine if it is proving beneficial.

Serzone may impair motor coordination, concentration, and judgment. Driving or operating machinery could be hazardous.